What the result means—and what care actually helps
Dr. Chukwuma Onyeije · Maternal-Fetal Medicine
MTHFR helps process folate. A common variant may modestly change enzyme activity, but it does not predict a pregnancy complication.
Do not screen for common MTHFR variants. They are not an inherited thrombophilia and do not independently guide pregnancy treatment.
People with MTHFR variants process folic acid. Take at least 400 mcg daily before and during pregnancy, unless advised otherwise.
Routine testing is unnecessary. If already elevated, investigate nutrition, kidney function, medicines, and other causes with your clinician. Treat the cause—not genotype.
Medication and supplement decisions should be based on your complete medical and pregnancy history.
Use evidence. Treat the person. Protect the pregnancy.